Extracorporeal membrane oxygenation (ECMO) is a high-risk low-frequency emergency procedure. A significant need exists for a low-cost and realistic Pediatric ECMO cannulation trainer that enables more versatile training options. Easily accessible training videos addressing unique challenges in the critical care clinical environment are indicated as well. Our goals are to create an inexpensive, anatomically accurate, reproducible standard for Pediatric ECMO cannulation simulation that can be distributed nationally and internationally. Our secondary goal was to document and vet our innovation processes which can be utilized for future projects and shared with others. The project team incorporated innovation processes, end user feedback, and quality improvement tools (4 PDSA cycles) to develop and finalize the new design and prepare for a new product evaluation pilot. The Pediatric ECMO Cannulation Trainer is an anatomically accurate model designed by front-line innovators to simulate all steps for cut down (not percutaneous) Pediatric ECMO neck cannulation in an 18-25kg patient. The Model includes two major components; Neck simulator (single use) and heart (reusable). The clear 3D printed heart provides visualization during insertion of the wire/cannula. The neck simulator consists of; right side of neck with anatomically accurate landmarks, realistic tissue layers for cutting and spreading to expose the vessels, correct vessel (IJV/Carotid) positioning, color, and feel for cutting, suturing and cannula insertion. A ECMO cannulation tips and techniques skills video demonstrating cannulation and connecting to the ECMO circuit was developed to complement the task trainer. Three takeaway lessons we will review in the presentation. 1.Identify strategic steps in the proof-of-concept development process. 2.Discuss the significance of interdisciplinary collaboration and end user engagement in proof-of-concept development. 3.Describe how to incorporate simulation, cost-effective tools, and equipment for proof-of-concept development.